Conductive nanofibrous scaffold based on polyvinyl alcohol/cellulose nanocrystals/ reduced graphene oxide composite reinforced with curcumin for wound healing

Document Type : Research Paper

Authors

1 Department of Chemistry, Payame noor University, Tehran, Iran;

2 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Sarvaran Chemie Pishro Company(S.C.P), Tabriz, Iran; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3 Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Conductive polymers offer great potential in skin tissue regeneration due to the promoted cellular activity and accelerate healing process. Herein, a polymeric nanofibrous dressing was prepared based on oxidized-nanocrystal cellulose/aminated reduced graphene oxide and polyvinyl alcohol (AD-CNCs/NH2rGO/PVA) to enhance cell proliferation with electrical fields for wound healing. For this purpose, CNCs were produced from cotton cellulose and oxidized in the presence of sodium periodate. Following the synthesis of rGO and its functionalization with amine, the crosslink between oxidized CNCs and NH2rGO was created by the Schiff-base reaction. The prepared nanocomposite was mixed with PVA and different proportions of curcumin. The polymeric nanofibrous scaffolds were prepared by electrospinning. With the increase in curcumin content, the hydrophobicity of the composition and the diameter of the nanofibers increased, while the uniformity and mechanical properties were optimized. The PVA/AD-CNCs/NH2rGO/curcumin nanofibrous scaffold exhibited electrical conductivity and satisfactory thermal stability. The PVA/AD-CNCs/NH2rGO/curcumin biodegradable nanofibrous scaffold was biocompatible and presented a satisfactory performance in cell attachment, proliferation and spreading, requirements for wound healing purposes.

Keywords

References

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Journal of Ultrafine Grained and Nanostructured Materials
Volume 57, Issue 1
June 2024
Pages 92-103

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History

  • Receive Date: 18 November 2023
  • Revise Date: 15 May 2024
  • Accept Date: 15 June 2024

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