Conductive Bio-Copolymers based on Pectin-Polycaprolactone/Polyaniline and Tissue Engineering Application Thereof

Document Type : Research Paper

Authors

1 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

3 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

4 Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

5 Chemical Engineering Department, Faculty of Engineering, Azarbaijan Shahid Madani University, Tabriz, Iran

6 Stem Cell Research Center, Stem Cells and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical

Abstract

Development of biopolymers possessing both biodegradable and electrically conducting properties has attracted a huge interest in the biomedical field. These systems have some benefitials in wound healing and reducing the long-term health risks. In this study, the pectin-polycaprolactone (Pec-PCL) copolymers were synthesized by ring-opening polymerization. Subsequently, the solutions of the synthesized Pec-PCL and homopolyaniline (H-PANI) were blended in various ratios and their conductivity properties were measured by cyclic voltammetry and the composition of 80:20 was selected for electrospinning process because of the suitable electroactive behavior and biodegradability. The morphology, biocompatibility, hydrophilicity, and mechanical properties of the nanofibers were thoroughly investigated. Resulted scaffolds represented a porous structure with large surface area (110–130 nm) and Young’s modulus of 1615 ± 32 MPa, which imitated the natural microenvironment of extra cellular matrix (ECM) to regulate the cell attachment, proliferation and differentiation. The results demonstrated that these electrospun nanofibers could be potentially applied in biomedical such as tissue engineering.

Keywords

References

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Journal of Ultrafine Grained and Nanostructured Materials
Volume 54, Issue 1
June 2021
Pages 64-72

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History

  • Receive Date: 27 July 2020
  • Revise Date: 30 November 2020
  • Accept Date: 21 December 2020

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