TY - JOUR ID - 79221 TI - Preparation and physical characterization of Adonis vernalis aqueous leaf extract-mediated green synthesized silver nanoparticles and its toxicity effect on breast cancer cells JO - Journal of Ultrafine Grained and Nanostructured Materials JA - JUFGNSM LA - en SN - 2423-6845 AU - Sattari, Roshana AU - Khayati, Gholam Reza AU - Hoshyar, Reyhane AD - Department of Materials Science and Engineering, Shahid Bahonar University of Kerman, Kerman, Iran. AD - Cellular and Molecular Research Center, Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Y1 - 2020 PY - 2020 VL - 53 IS - 2 SP - 183 EP - 189 KW - Green Synthesis KW - Silver nanoparticles KW - Adonis vernalis extract KW - Breast Cancer KW - MTT assay DO - 10.22059/jufgnsm.2020.02.10 N2 - The specific characteristics of silver nanoparticles (AgNPs), especially anticancer and antimicrobial properties, have led to their widespread usage in biology. The study looked at the anti-cancer activity of AgNPs, which were produced by a one-step green synthesis based on the use of Adonis vernalis leaf extract. Characterization of reducing agents in plant extracts was performed using (FT-IR) infrared spectroscopy. The presence of adsorption peak at 442 nm in UV-visible absorbance of bio-fabricated AgNPs indicates the effectiveness of proposed method. Transmission electron microscope (TEM) and field emission electron microscope (FESEM) were used to investigate the morphology and confirmed the spherical shape of products. Phase analysis and determination of the synthesized product crystal lattice was performed using X-ray diffraction (XRD) method. The stability of particles was determined using zeta potential analyze. Energy-dispersive X-ray (EDX) analysis confirmed the formation of high purity AgNPs. The MTT assay was used to determine the anti-toxic properties of produced products and the results demonstrated that silver nanoparticles biosynthesized by Adonis vernalis extract can be used to treat breast cancer. UR - https://jufgnsm.ut.ac.ir/article_79221.html L1 - https://jufgnsm.ut.ac.ir/article_79221_2a7bbf946a88077b97e1176f29108087.pdf ER -